Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 34th International Conference on Neonatology and Perinatology Paris, France.

Day 1 :

Conference Series Neonatology 2020 International Conference Keynote Speaker Masatoki Kaneko photo
Biography:

Masatoki Kaneko speciality is Obstetrics & Gynecology, and Neonatology. He studied at University of Miyazaki and Lauson Research Institute, University of Western Ontario, Canada. He is the dean of Graduate School of Nursing Science. He has published more than 35 papers in reputed journals and has been serving as a board member of Japan Society of Maternal Health and the president of Miyazaki Society of Maternal Health. He received a Young Investigator Award, Japan Society of Obstetrics and Gynecology in 2001.

Abstract:

Aim: We established a model to predict high cytomegalovirus (CMV) immunoglobulin (Ig)G avidity index (AI) levels using clinical information to contribute to the mental health of pregnant women with positive CMV IgM.

Method: This retrospective cohort study included 371 pregnant women with IgM positivity at <14 weeks of gestation. Information on women was obtained from medical charts. Congenital infection was confirmed by polymerase chain reaction using amniotic fluid or neonatal urine. The IgG AI cutoff value for diagnosing congenital infection was calculated based on receiver operating characteristic curve analysis. Between-group differences were assessed using Mann–Whitney U-test or χ2 analysis. Factors predicting high IgG AI were determined using multiple logistic regressions.

Results: There were 10 congenital infections, and the cutoff value of 31.75 for IgG AI was optimal in pregnant women for diagnosing congenital infection in their newborns. The pregnant women were divided into two groups (high or low IgG AI groups based on IgG AI cutoff value). There were significant differences in the IgG and IgM levels, maternal age, clinical signs, and number of women with one parity between the two groups. These five predictor variables were included in the model. The significant predictors for high IgG AI based on our logistic regression analysis were IgM and the number of women with one parity. This model correctly classified the IgG AI level for 84.6% women.

Conclusion: This model is highly effective in predicting high IgG AI and enables in reassuring pregnant women immediately after the judgment of IgM positivity.

  • Neonatology

Session Introduction

Marwa Alkotamy

The Royal Wolverhampton NHS Trust, UK

Title: Early initiation of breastfeeding audit in preterm babies admitted to neonatal unit
Biography:

Marwa Alkotamy is a paediatric trainee at Univeristy Hospital of North Midlands, UK. She is member of Royal College of Paediatrics and Child health and she had MBBCH in 2009 from Alexandria University in Egypt. She has worked since then as a paediatric registrar in Saudi Arabia and joined paediatric training program in West Midlands Hospitals in UK.

Abstract:

Early initiation of breast feeding is a key factor of neurodevelopment of preterm babies and one of the measures of NNAP is to assess if babies born less than 32 weeks gestational age receive their mother’s milk at day 14 of life and at discharge.

Objectives:

  • To assess rates of initiation and maintenance of breastfeeding
  • To assess average time taken to achieve full feeds
  • To develop an action plan around improving our breastfeeding experience for our babies

Method: Prospective study of babies born less than 34 weeks gestation over period of four months. Proforma was network based and data was collected via Badger network.

Results: Total of 70 babies between 25+5 to 33+5 weeks included. 39 babies were born via caesarean section and 31 born via NVD with 18 multiple births. All babies whom mothers wanted to breast feed received breast milk as the first feed. 86% of all babies received breast milk at some point and 54% of them received breast milk within 48 hours of birth. The main reason for delaying breast feeding was non-availability of mother’s milk. Breast feeding rates was reduced in babies delivered via cesearean section and gradually declined during admission.

Conclusion: There is need to offer breastfeeding support throughout the admission to mothers to ensure sustainability. An expression checklist was designed towards achieving this.

Ryan Zia Arslaan

Karaganda Medical University, Kazakhstan

Title: Depression, COVID and migrants
Biography:

Ryan Zia Arslaan is student of 3rd year General Medicine Studying in Karaganda Medical University, Kazakhstan. He worked on publications related to coronavirus and aimed to continue it.

Abstract:

Background: Mental pain is more dramatic and painful than physical pain. It is more common and harder to bear as we know it’s more comfortable to complain my leg is paining despite "my head feels like hammered or poked". The aim of this study on migrant laborers working in Kazakhstan conducted aiming to discover their suffering due to the COVID outbreak. We interviewed Indian migrant workers associated with our university, were selected, questioned, and physically examined. And found whereas, in depression, a person suffers feelings of loss; we can say it is something more significant than the feeling of sadness. Depression is a severe terminology it expands for 14 days, and we clinically label a person depress when the person has at least 2 of the following three symptoms, as a medical student I remember it by pneumonic "EMI" (energy, mood and interest respectively ). Not only can these other symptoms be seen in a depressed patient like loss of concentration, guilt, sleeplessness etc.

While examining the migrants, we also try to find whether it is hereditary or not as we know the first cause of depression can be biological, and it can be due to genes of depression or abnormality in the frontal lobe of the brain. In a patient suffering from depression, it observed that their frontal lobe is smaller than usual and shrink hippocampus are present in them. 

The remaining causes of depression also so that we can get a bigger picture of our topic, so the other causes of depression are malfunctioning of Neurotransmitter to be more definite lack of Serotonin, dopamine and non-epinephrine can cause depression but not to worry we have tablets which can increase its level in our body. We can say till now we have discussed all the causes of depression.

Coming back to our research, we not only determine the depression we also focused on its severity, it’s possible reasons, outcomes, and we assisted them with treatment too. 

Almost 60% were depressed since they suffer hopelessness, loss of interest, sadness, lack of knowledge about the pandemic. 20% suffer excess sleepiness, and around 20% suffer fatigue, loss of appetite, all suffer weight gains, job insecurity. No one was observed as healthy as before due to depression. We conclude by this study demonstrates that urgent need for health and mental health care for migrant laborers needs to be provided and knowledge related to pandemic shall also be provided by the personalized conference, especially for central Asian laborers.

Biography:

Fatemeh Eghbalian has completed his MD at the age of 25 years from Isfahan University of Medical sciences and pediatrics and neonatology from Tehran University of Medical sciences. She is Professor of Neonatology and director of NICU ward. She has published 3 books and more than 40 papers in reputed journals.

Abstract:

Esophageal atresia is often associated with anomalies of other systems. Hereditary and environmental factors may influence the incidence of associated anomalies, particularly of the cardiac abnormalities. The aim of this study was to investigate the frequency of cardiac abnormalities and other associated anomalies in newborns with esophageal atresia. This retrospective Descriptive- Cross sectional study was conducted on 63 neonates with esophageal atresia hospitalized at Besat Hospitals. The documents were evaluated and data such as age, sex, and birth weight, cardiac and other associated anomalies were recorded and entered the questionnaires.  63 neonates were enrolled in the study. 38 (60.3%) cases were female and 25 (39.7%) were male. The mean age of neonates was 2.33+1.9 days (1-11 days), and mean birth weight was 2678.6 + 511.3gr (1350-3600gr). Cardiac abnormalities were present in 7 (12%) cases. Tracheoesophageal fistula was present in 54(85.7%) cases. 15.9% of neonates had other anomalies. Urinary tract anomalies were present in 3.17% cases. Other associated anomalies were anorectal anomalies (4 neonates), and limb anomaly (1 neonate).

This study showed that 15.9% of neonates (with or without tracheoesophageal fistula) had other anomalies. The most common anomalies were cardiovascular, anorectal, and renal anomalies. Detection of associated anomalies with esophageal atresia requires clinical examination, pre-operative renal ultrasound and an echocardiograph of the heart to exclude congenital renal and heart disease.

Biography:

Noormah Mehmood has completed his Medical degree at the age of 25 years from the Aga Khan University, Pakistan and her pediatric residency at Texas A&M College of Medicine/Driscoll Childrens Hospital. He is the Chief Resident at Driscoll Children’s Hospital. He has published several articles in reputed journals.
 

Abstract:

Introduction: Deformational Plagiocephaly (DP) is the abnormal flattening of the skull. DP has been associated with abnormal brain shape and worse neurodevelopmental outcomes on the Bayley Scales of Infant and Toddler Development-III (BSID-III). In 2009, the FDA approved a repositioning Beanie for prevention of flat head. 
Purpose: To assess the impact of the use of the Beanie on neurodevelopment of preterm infants with DP admitted in the NICU using the BSID-III.
Methods: Retrospective chart review was performed between January 2013-2017. Infants less than 32 weeks gestational age, under 1500g birth weight and attending high risk follow-up clinic were included. Patients with congenital cardiac defects, hypoxic ischemic encephalopathy and severe neurologic impairment were excluded. The Beanie was used for patients diagnosed with DP. BSID-III for patient’s language, motor and cognition was performed at the 12- and 24-months follow-up. 
Results: 207 patients met the inclusion criteria and 105 patients were females and 102 males. The gestational age ranged between 22.5-31.5 weeks. The birth weight ranged between 460g and 1460g. The Beanie was used in 32 patients. 31 Patients followed up 12 months and 16 patients at 24-months. 12-month Bayley cognition scores were found to be statistically improved in babies who used the Beanie. 
Conclusion: Repositioning Beanie is an inexpensive way, to prevent DP which in turn could improve the neurodevelopmental outcomes. The study showed significant improvement in 12-months cognition Bayley scores but was not appreciated at 24-months cognition scores which could be due to lower sample size at 24-months.

Biography:

Velur Balasubramaniam is a Consultant Neonatologist with special interest in cardiology and congenital infections at the University Hospitals of Derby and Burton. He is the clinical lead for neonatal clinical governance and has been a training programme direction for postgraduate education in the Health Education England (East Midlands). He has published 10 articles in peer reviewed international medical journals. 

Abstract:

Methaemoglobinaemia occurs when methaemoglobin concentration in erythrocytes exceeds 1%. Acquired methaemoglobinaemia is more common than congenital and can occur after exposure to certain oxidant drugs.

In our hospital, over an 8 year period (2009-2017), of 48000 births, 8 infants presented with methaemoglobinaemia. These included 6 cases of acquired methaemoglobinaemia. Infants presented with duskiness, low oxygen saturations (74-90%) but normal/high arterial partial pressure of oxygen (9.2-18.7 kPa). They had normal glucose-6-phoshphate dehydrogenase (checked in 4 infants) and normal echocardiograms.  One infant, born at term gestation, developed nectrotising enterocolitis needing surgical intervention. Five infants received and responded to methylene blue treatment.

In five infants, case review revealed that local prilocaine injection was given to the mother during labour for episiotomy. Prilocaine can induce methaemoglobinaemia. The incidence of neonatal methaemoglobinaemia after prilocine for episiotomy is estimated to be 0.37% (1).

The use of local anaethetic for episiotomy was reviewed and prilocaine was replaced by lignocaine in 2017. No further cases of methemoglobinemia have been reported since.

This high incidence (0.17 per 1000 births) of acquired methaemoglobinaemia may have been related to Prilocaine exposure. Acute acquired methaemoglobinaemia is an emergency and should be considered if cyanosis occurs with normal arterial oxygenation. Treatment with methylene blue is recommended if methemoglobin level is >20%. An extraordinary increase in incidence of rare conditions should trigger an overarching review of clinical practice. As in this report, root cause can be detected and change in clinical practice implemented to prevent further cases.

Sarhan Alshammari

King Abdulaziz Medical City, Saudi Arabia

Title: Neonatal outcomes of infants with ABO incompatibility
Biography:

Sarhan Alshammari has completed his PhD at the age of 26 years from Dammam University and postdoctoral studies from Dammam University School of Medicine. He finished his Saudi board pediatric residency program and completed his fellowship in Neonatology in King Abdulaziz Medical City Riyadh. He is working as neonatologist in Maternity and Childhood hospital in Saudi Arabia.

Abstract:

Background: ABO blood group incompatibility occurs in 15-20% of all pregnancies and 10% of those develop hemolytic disease. Transcutaneous bilirubin screening use is increasing but still not widespread.

Aims: To compare neonatal outcomes of DCT positive and DCT negative infants born to blood group O positive mothers to evaluate the effect of neonatal blood group on the severity of hemolysis and neonatal jaundice due to maternal-fetal ABO incompatibility. To investigate the value of transcutaneous bilirubin measurement and first serum bilirubin in predicting the development of significant hyperbilirubinemia later in the first few days in infants with ABO incompatibility.

Methodology: One year retrospective review of infants with blood group A and B positive born to Blood group O positive mothers with gestational age of > 33 wks. at birth.

Results: Hyperbilirubinemia outcomes by coombs test status, hyperbilirubinemia outcomes by infant’s blood group status and prediction of intense phototherapy using TCB, first serum bilirubin levels among DCT positive infants.

Conclusions:

  • There was significant difference in the incidence and severity of hyperbilirubinemia and hemolysis between DCT negative and positive infants.
  • Infants with blood group B positive had more severe hemolysis as evidenced by need for PT, IVIG therapy and the duration of hospital stay.

Estimation of TCB after birth is useful in predicting which infants will develop severe hyperbilirubinemia.

Biography:

Steven A. Seepersaud completed his MD from Greenheart Medical University, Guyana with Caribbean Association of Medical Councils certification. He is currently pursing his Master’s in Public Health (MPH) at the University of Liverpool. He has a special interest in paediatrics and neonatology which drives his passion for research.

Abstract:

Objectives: (1) To evaluate survival of very preterm infants admitted to the NICU at GPHC from 2015 to 2017. (2) To assess associated long-term outcomes of these infants. (3) To make recommendations on the follow-up of very preterm infants.

Design and Methods: For phase I (cross-sectional), charts for all preterm infants admitted to the NICU at GPHC from 2015 to 2017 were pulled and outcomes were recorded (discharge or death). For phase II (retrospective cohort), surviving very preterm infants were randomly selected from a pool of 143 infants until a quota of 35 patients per year (105 total) was reached to achieve a confidence level of 95%. Parents were contacted via phone, and the Ages & Stages Questionnaires were conducted with consent.

Results: There was a significant association between GA and survival for preterm infants admitted to the NICU at GPHC from 2015 to 2017 (χ² (2)=85.044, p<0.001). Very preterm infants scored poorly in all ASQ categories except gross motor category. There was no significant association between time spent in the NICU or mode of delivery and ASQ scores (χ² (68)=79.137, p=0.205; χ² (2)=1.879, p=0.449) or parental concerns (χ² (102)=122.749, p=0.079; χ² (3)=1.775, p=0.620).

Conclusion: Survival of preterm infants is directly proportional to GA. Moreover, overall survival of very preterm infants admitted to the NICU at GPHC was survival 51% during periods of study.  Gross motor was the only developmental category that appeared to be on schedule for these very preterm infants. However, overall development among these infants was very poor, especially with language and speech.

Biography:

Odattil Geetha has completed her MBBS from Calicut University and MRCPCH in 2005. She is a fellow of academy of medicine of Singapore since 30 April 2018. 

Abstract:

Introduction: Continued high prevalence of Broncho Pulmonary Dysplasia (BPD) with its long-term morbidity favors development of an accurate BPD prediction model to enable preventative measures and improved counselling.

Aims: Primary aim of this study was to evaluate the validity of the modified NICHD scoring system for prediction of BPD/Mortality in Asian extremely low birth weight (ELBW) infants.